TEST and NOT GUESS!
CYREX LABORATORIES – ARRAY #3X / ARRAY #4 / ARRAY #10/ Array #10-90/ Array #10-90X
The Cyrex Laboratories Array #3X, Array #4, and Array #10 test for antibodies against a number of various foods.
ARRAY #3X: Wheat/Gluten Proteome Reactivity and Autoimmunity
Cyrex Laboratories Array #3X measures antibody production (IgG/IgA) against several wheat proteins and peptides and 3 essential structure enzymes to help you accurately identify gluten sensitivity.
MARKERS INCLUDED ON THIS TEST:
- Wheat IgG/IgA
- Wheat Germ Agglutinin IgG/IgA
- Non-Gluten Proteins A & B IgG/IgA
- Gliadin Toxin Peptides IgA/IgG
- Native & Deamidated Gliadin 33 IgG/IgA
- Gliadin Peptides: Alpha-Gliadin-17-Mer IgG/IgA, Gamma-Gliadin-15-Mer IgG/IgA, Omega-Gliadin-17-Mer IgG/IgA, & Glutenin-21-Mer 33 IgG/IgA
- Gluteomorphin + Prodynorphin IgG/IgA
- Gliadin-Transglutaminase Complex IgG/IgA
- Microbial Transglutaminase IgG/IgA
- Transglutaminase-2 IgG/IgA
- Transglutaminase-3 IgG/IgA
- Transglutaminase-6 IgG/IgA
Advantages of this test: Considered the “Rolls Royce” of gluten sensitivity panels, Array #3 is the best gluten sensitivity test available because it tests for numerous ways an individual can react to gluten. Most tests only check for antibodies to alpha-gliadin (one single gluten peptide), and not everyone with a gluten sensitivity reacts to that particular gluten peptide. A couple of the markers also can indicate whether the individual is on the “Celiac Disease spectrum” (rather than just simply having a non-celiac gluten sensitivity). Additionally, it can tell you if gluten is causing an opiate-like response which can disrupt brain function, alter behavior, and cause food and other addictions.
ARRAY #4: Gluten-Associated Cross-Reactive Foods & Foods Sensitivity
Cyrex Laboratories Array #4 measures antibody production (IgG/IgA) against foods that contain gluten (rye, barley, spelt, polish wheat), foods that are known to cross-react with gluten (dairy, yeast, oats, millet, rice, and corn), foods that are newly-introduced and commonly over-consumed on a gluten-free diet (rice, sorghum, quinoa, etc), and foods that are common allergens (corn, soy, eggs, etc).
MARKERS INCLUDED ON THIS TEST:
- Rye, Barley, Spelt, Polish Wheat (sources of gluten)
- Dairy (cow’s milk, casein, casomorphin, milk butyrophilin, whey protein, chocolate milk [processed dairy])
- Gluten-Free Grains & Grain-Like Seeds (amaranth, buckwheat, hemp, millet, oats, potato, quinoa, rice, sesame, sorghum, tapioca, teff)
- Yeast
- Coffee (instant – which is almost always contaminated with gluten during processing)
- Common Food Allergens (soy, egg, corn)
Advantages of this test: This is one of the best tests for detecting a dairy sensitivity because it includes 6 different dairy markers. It can be very helpful to detect cross-reactions in an individual who is non-responsive on a gluten-free diet and to uncover that missing link blocking the body from healing. Additionally, it can provide direction on whether a standard gluten-free diet (which includes gluten-free grains and seed-like grains like rice, sorghum, and quinoa) is sufficient or whether a grain-free (Paleo-style) diet may be best at this time because the body has become sensitized to those proteins.
ARRAY #10: Multiple Food Immune Reactivity Screen
Cyrex Laboratories Array #10 measures antibody production (IgG/IgA) against 180 different foods (raw and/or modified), foods enzymes, lectins, and artificial food additives (including meat glue, colorings, and gums).
Cyrex Laboratories Array #10-90 measures antibody production (IgG/IgA) against 90 of the most common foods from Array #10 including (raw and/or modified), foods enzymes, lectins, and artificial food additives (including meat glue, colorings, and gums).
Cyrex Laboratories Array #10-90X measures antibody production (IgG/IgA) against the remaining foods from Array #10 including (raw and/or modified), foods enzymes, lectins, and artificial food additives (including meat glue, colorings, and gums).
MARKERS INCLUDED ON THIS TEST:
- Fruits
- Vegetables
- Grains
- Beans & Legumes
- Nuts & Seeds
- Fish & Seafood
- Meat
- Dairy & Eggs
- Spices
- Herbs
- Gums
- Brewed Beverages & Additives
Advantages of this test: Cyrex says that this panel is “The New Standard in Food Immune Reactivity Testing.” While most labs use purified RAW proteins for their test panels, Cyrex acknowledges that this does not factor in how we commonly consume certain foods. In order to test “real world exposures to real food,” Cyrex tests for both RAW and COOKED forms of foods on this panel. Heating food above 118°F changes a food’s protein structure and therefore its antigenicity. As a result, an individual could react to the cooked form of a food but not the raw form, and vice versa. For example, maybe a previous food sensitivity panel said that broccoli was non-reactive for you, but you notice that you experience negative symptoms whenever you eat it. If you were tested for broccoli using a standard RAW broccoli extract, then you may test non-reactive, but that doesn’t necessarily mean that COOKED broccoli is non-reactive as well. So, perhaps you are sensitive to the protein structure in COOKED broccoli but not the form in raw broccoli, but the problem is, you always eat your broccoli cooked. Since we eat our meat cooked, that’s how Cyrex tests those proteins – as cooked beef/chicken/pork. Many vegetables are frequently eaten either cooked or raw, so Cyrex tests both forms in a number of cases (i.e. broccoli).
TEST DETAILS (FOR ALL CYREX TEST PANELS):
- Test Type: Blood (1 vial)
- Shipping: The blood draw location will ship your blood directly to Cyrex Labs by UPS using the bag with your kit (leave the kit with them and they will take care of the rest). Blood may NOT be shipped on Friday (if the blood is collected on a Friday, it must be kept refrigerated over the weekend and shipped on Monday).
- Cost:
- Array #3: $325 + shipping ($8 within the U.S. to drop-ship from FDN)
- Array #4: $225 + shipping ($8 within the U.S. to drop-ship from FDN)
- Array #10: $580 + shipping ($8 within the U.S. to drop-ship from FDN)
- Array #10-90: $339 + shipping ($8 within the U.S. to drop-ship from FDN)
- Array #10-90X: $339 + shipping ($8 within the U.S. to drop-ship from FDN)
- Array #3, #4, and #10 can be bundled together for a discount:
- Array #10 (Array #3, #4, & #10): $995 + shipping ($8 within the U.S. to drop-ship from FDN)
- Array #10-90 (Array #3, #4, & #10-90): $824 + shipping ($8 within the U.S. to drop-ship from FDN) [Array #10-90 is a smaller version of Array #10 and includes the top 90 antigens from the Array #10 panel)
- Note: All 3 arrays must be ordered at the same time to receive this bundle discount. There is only one MDP fee of $75 for the 3-test bundle.
- Additional Info:
- Only 1 test kit is needed for multiple Arrays.
- Cyrex freezes the submitted blood sample for 90 days. In that time frame, if you’d like you run another Array, the lab can use that same sample.
- There is a discount for running Array #3, Array #4, and Array #10 at the same time.
- The test cannot be done in New York state. The client’s address can be in New York, but the blood must be drawn in CT, NJ, PA, etc.
- If you use one of the draw sites Cyrex contracts with, there is no additional fee for the blood draw (note: contracted sites will NOT draw blood for individuals under 15 years of age). However, you may have your blood drawn at a location of your choice such as a local hospital lab. Just be aware that there will likely be a small fee for this service.
- The turnaround time for testing is 14 days from the time the sample arrives at the lab.
- Canada: The client will be responsible for finding a blood draw location and return shipping. 2-day shipping is always recommended for International shipments, but the lab only rejects samples that were drawn longer than 10 days prior to it receiving them. Be sure to include the CDC permit and label.
- Cyrex Labs always analyzes each sample TWICE. If there is more than a 3% discrepancy, the sample is analyzed for a 3rd time. If there is still more than a 3% discrepancy, the sample is thrown out, and they ask for a new sample. So, you can have confidence in the accuracy of the test results that you get back.
- The client MUST be eating the foods that are to be tested. Antibody production is dependent upon exposure to a food.
- To test for gluten sensitivity (Array #3), the client MUST be currently consuming gluten at the time of the test to get an accurate result. If someone has been 100% strictly gluten-free for over 3-6 months, antibody levels should be minimal or gone (unless there is cross-reactivity, cross-contamination, or some other exposure to gluten), so you may get a false negative. While a challenge test (re-introducing gluten to test if it’s a problem) is NOT recommended, if the patient insists on a gluten challenge, this may be done by thoroughly chewing HALF A WHEAT CRACKER PER DAY FOR 2 WEEKS. After eating gluten for these 2 weeks, the client should wait for 2 weeks, and then test. Gluten challenging with larger quantities can be traumatic for the body, so only this small amount of gluten is consumed.
- To test for sensitivities to other foods (Array #4 & Array #10), these foods must be part of the client’s diet. For example, if the client has been completely avoiding dairy, there should not be antibodies against dairy. Or, if the client is eating the Standard American Diet (which typically does not include foods that are “staples” in the typical gluten-free diet like rice, sorghum, quinoa, and tapioca), they will not have antibodies against these gluten-free grains. It will be necessary to include these foods in the diet to stimulate antibody production and get accurate test results. It typically takes 4-6 weeks of daily or regular exposure to a small amount of the food (a bite or two is usually sufficient), so add the foods into the diet for 4-6 weeks, then wait another 2-4 weeks for antibodies to develop, then test. If individuals know that they are sensitive to a particular food and have already eliminated it, it is not recommended to add that food back into the diet. Instead, use the test (without food reintroduction) to indicate whether they have successfully reduced the elevated antibodies to this food.