Thyroid Function
- Thyroid Hormone Production:
- Energy Balance: The thyroid gland produces hormones (T3 and T4) that regulate metabolism. Chronic fasting can signal to the body that energy intake is low, leading to a reduction in thyroid hormone production to conserve energy.
- Conversion of T4 to T3: T4 is converted to the more active T3 in various tissues. Fasting and caloric restriction can decrease this conversion, leading to lower levels of T3, slowing metabolism, and conserving energy.
- Stress Response:
- Cortisol: Chronic fasting increases cortisol levels, a stress hormone that can interfere with the hypothalamic-pituitary-thyroid (HPT) axis. Elevated cortisol can inhibit the release of thyroid-stimulating hormone (TSH) from the pituitary gland, which is necessary for thyroid hormone production.
- Sympathetic Nervous System Activation: Prolonged fasting keeps the body in a state of sympathetic activation (fight or flight response), which can further disrupt thyroid function and hormone balance.
Luteinizing Hormone (LH) Pulses
- Hypothalamic-Pituitary-Gonadal (HPG) Axis:
- Gonadotropin-Releasing Hormone (GnRH): The hypothalamus releases GnRH in pulses to stimulate the pituitary gland to release LH. Chronic fasting can disrupt the frequency and amplitude of these pulses.
- Energy Availability: Adequate energy is crucial for regular GnRH pulses.
- Low energy availability due to chronic fasting can lead to irregular or diminished GnRH pulses, affecting LH secretion.
- Impact on Reproductive Health:
- Menstrual Irregularities: LH is essential for ovulation and maintaining regular menstrual cycles.
- Disrupted LH pulses can lead to irregular menstrual cycles, anovulation (lack of ovulation), and other reproductive issues.
- Hormonal Balance: LH is also important for maintaining levels of other reproductive hormones such as estrogen and progesterone. Disrupted LH pulses can lead to hormonal imbalances, affecting overall reproductive health and well-being.
Summary – Chronic fasting can lead to a cascade of hormonal disruptions:
- Thyroid Function: Reduced thyroid hormone production and conversion, primarily due to energy conservation and elevated cortisol.
- LH Pulses: Disrupted GnRH and LH pulses due to low energy availability, leading to irregular menstrual cycles and hormonal imbalances.
Overall, the stress and energy deficits associated with chronic fasting can significantly impact both thyroid and reproductive health, particularly in women.
The mechanism of action for females regarding the timing of cortisol peaks and its relationship with food intake involves several physiological processes:
Cortisol and Circadian Rhythm
- Cortisol Awakening Response (CAR):
- Morning Peak: Cortisol levels naturally rise in the early morning and peak about 30 minutes after waking. This is part of the circadian rhythm, helping to wake the body and prepare it for the day’s activities.
- Role of Cortisol: Cortisol helps regulate metabolism, immune responses, and stress. It increases blood sugar levels to provide immediate energy, supports alertness, and helps manage physical and psychological stress.
Impact of Delaying Food Intake
-
Sympathetic Nervous System Activation:
- Increased Sympathetic Drive: Delaying food intake can prolong the body’s sympathetic (fight-or-flight) response, which is naturally high in the morning due to elevated cortisol levels.
- This can keep the body in a heightened state of stress.
- Stress Hormone Cascade: Without food, the body may perceive a continued lack of energy availability, maintaining high cortisol levels and further activating the sympathetic nervous system.
-
Glucose and Energy Regulation:
- Gluconeogenesis: Without food intake, the body may increase gluconeogenesis (production of glucose from non-carbohydrate sources) to maintain blood sugar levels. This process is cortisol-dependent and can increase cortisol levels further.
- Blood Sugar Fluctuations: Stable blood sugar levels are crucial for cognitive function. Prolonged fasting can lead to blood sugar fluctuations, impairing cognitive performance and mood.
Summary of Pre-Workout Nutrition Tips:
Balanced Pre-Workout Snack:
- Example: Double espresso with almond milk and protein powder.
- Almond Milk: Provides carbohydrates.
- Protein Powder: Supplies protein.
Nutritional Approaches for Different Workouts:
- Endurance Sessions:
- Nutrition: Carbs and protein.
- Example: Combining sweetened almond milk (carbs) with protein powder.
- Gym Workouts:
- Nutrition: Protein suffices.
- Example: Protein powder in coffee.
Caffeine Intake:
- Provides energy and calories for the hypothalamus.
Research Insights:
- Strength Training:
- Recommended Intake: Around 15g of protein pre-workout.
- Benefits: Fuels the body and enhances recovery.
- Cardiovascular Workouts (lasting up to an hour):
- Recommended Intake: Add 30g of carbs.
Pre-Workout Snacks:
- Not full meals but sufficient to raise blood sugar and stimulate the hypothalamus.
Post-Workout Nutrition:
- Recommendation: A full breakfast within 45 minutes post-workout for optimal recovery.
Focus of Pre-Workout Nutrition:
- Impact on the brain and neurons, beyond just calorie intake and expenditure.
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[Dr. Stacy Sims] (9:49 – 12:50)
So oxidative fibers are muscle fibers that are more aerobic capacity. So those are the ones that you can go long and slow for a very long period of time because it uses a lot of free fatty acids. You need a little bit of glucose in order to activate those free fatty acids. So when we look when a woman starts to exercise, she goes through blood glucose first and then gets into free fatty acid use. She doesn’t tap so much into liver and muscle glycogen, which is, I think, another misconception that happens. So when we’re talking about fasting or fasted workouts, trying to improve that metabolic flexibility, it increases stress on the woman.
And so when we’re talking about overall stress, we’re talking about cortisol increase, and they can’t hit intensities high enough with no fuel to be able to invoke the post-exercise responses of growth hormone and testosterone, which then drop cortisol. So from an overall stress perspective, that fasted workout and holding that fast for a long period of time increases cortisol. But then when we look from like a hypothalamic point of view and we’re looking at how the brain reads it, we know that there’s one area of kisspeptin neurons in the brain for men, but there are two for women.
So the two areas are distinct where one controls appetite and luteinizing hormone and the other one is looking at estrogen and thyroid. So if you start having an exercise stress or a daily stress of getting up and going on with your day without fuel, you perturb those kisspeptin neurons and downregulate them. So when you start downregulating them, we see that after four days, you have a dysregulation of thyroid. We have a change in our luteinizing hormone pulse, which is really important to maintain endocrine function. And we’ll hear this, oh, I’ve been fasting for so many years and it does great for me. But the other side of the question is, well, how much better would you be if you were to actually pay attention to your circadian rhythm and fuel according to the stress at hand and knowing that you’re going to garner less stress that way.
And if we’re really tying in nutrition according to that profile, instead of following a fast, we see better brain improvements as well. We see more cognitive function. We see less thyroid dysfunction and overall woman does much better when we’re not in that fasted state. Then when you look at population research that’s coming out now, they’re showing in both men and women who hold their fast till noon and then have an eating window from noon to maybe 6 p.m. have more obesogenic outcomes than people who break their fast at 8 and finished their eating window by 4 or 5 p.m. So it’s coming back to the chronobiology of we need to eat when our body is under stress and needs it. Unless we have a specific issue like obesity, inactivity, PCOS or other metabolic conditions, then we can look at using fasting as a strategic intervention to help with those modalities.
Summary and Explanation of Key Points
- Oxidative Muscle Fibers ([Dr. Stacy Sims] (9:49 – 12:50)):
- Definition: Oxidative fibers, or Type I fibers, are more aerobic and are efficient at using fatty acids for energy. These fibers support prolonged, low-intensity exercise.
- Fuel Utilization: During exercise, women initially use blood glucose before transitioning to free fatty acids. They use less liver and muscle glycogen compared to men.
- Fasted Workouts and Metabolic Flexibility:
- Impact on Stress: Fasted workouts increase cortisol levels, which can negatively impact the ability to reach high exercise intensities. High intensities are needed to stimulate growth hormone and testosterone, which help reduce cortisol.
- Effect on Endocrine Function: Fasted workouts can disrupt hypothalamic kisspeptin neurons, which play a role in regulating appetite, luteinizing hormone, estrogen, and thyroid function. This disruption can lead to thyroid dysregulation and changes in luteinizing hormone pulses.
- Circadian Rhythm and Nutrition:
- Importance of Timing: Adhering to circadian rhythms and properly timing nutrition can mitigate stress and support better metabolic outcomes. Eating in alignment with the body’s natural stress response improves cognitive function and endocrine health.
- Research Findings: Studies suggest that fasting until noon and eating from noon to 6 p.m. can lead to more obesogenic outcomes compared to breaking the fast earlier in the day and finishing eating by late afternoon.
- Strategic Use of Fasting:
- Conditions for Fasting: Fasting may be beneficial for specific conditions such as obesity, inactivity, or PCOS. However, for general health and optimal performance, it is important to eat according to the body’s stress levels and circadian rhythms.
Key Takeaways:
- Oxidative Muscle Fibers: Support long-duration, low-intensity exercise by efficiently using fatty acids.
- Fasted Training: Can increase cortisol and disrupt endocrine function, making it less effective and potentially harmful for women.
- Circadian Rhythms: Aligning eating with circadian rhythms and stress levels can enhance overall health and performance.
- Fasting Strategy: Use fasting strategically for specific health issues, but regular meal timing is generally better for maintaining metabolic health and function.
Summary and Explanation
[Timestamp: 2:22:56 – 2:24:36]
1. Importance of Quality Fuel for Women
- Need for Quality Fuels: Women should consume higher quality fuels to manage cortisol spikes and enhance their training experience and performance.
- Explanation: Proper nutrition helps stabilize cortisol levels and supports better training outcomes. Consuming quality fuels (nutrient-dense foods) can improve overall well-being and training efficiency.
2. Nutritional Context for Training
- Nutrition and Training Connection: Effective nutrition fuels training, which in turn drives physiological changes at the muscle and liver levels, enabling better fuel utilization.
- Explanation: A well-balanced diet supports muscle repair, energy production, and overall performance, making it crucial for optimizing training results and recovery.
3. Understanding Intrinsic Self
- Self-Awareness and Body Signals: Women should reconnect with their bodies and understand their intrinsic needs and responses, including menstrual cycles and perimenopause.
- Explanation: Self-awareness helps women navigate their hormonal cycles and implement appropriate external stressors, leading to improved health and well-being.
4. Sociocultural Influences
- Impact of External Noise: Women are often influenced by sociocultural rhetoric, which can obscure their understanding of their own bodies and needs.
- Explanation: Relearning how to listen to one’s body amidst external pressures is essential for making informed decisions about health and nutrition.
Key Evidence and Research:
- Quality Fuel and Cortisol: Research suggests that high-quality nutrition can help manage cortisol levels and improve exercise performance and recovery. Studies on nutrition and stress show that balanced diets help mitigate cortisol spikes.
- Nutritional Impact on Training: Exercise physiology research supports the concept that proper nutrition enhances training outcomes by fueling physiological processes related to muscle repair and energy metabolism.
- Self-Awareness and Hormonal Health: Evidence from hormonal research indicates that understanding one’s hormonal cycle and body responses is crucial for managing health, particularly during phases like perimenopause.
- Sociocultural Impact: Studies have shown that societal influences can affect how individuals perceive and respond to their health needs. Reconnecting with one’s intrinsic needs can counteract the negative effects of external pressures.
Overall Message from Dr. Stacy Sims on Huberman Lab Podcast
- Fueling and Training: Proper nutrition is crucial for managing cortisol and optimizing training outcomes.
- Self-Awareness: Women should focus on understanding their bodies and hormonal cycles to make informed health decisions.
- Addressing External Influences: Reconnecting with one’s intrinsic needs can help overcome societal pressures and improve health and well-being.
Huberman Lab Notes:
Summarize episode Dr. Stacy Sims: Female-Specific Exercise & Nutrition for Health, Performance & Longevity
Nutritional Guidelines:
- Protein Intake: Women should consume around 1 to 1.1 grams of protein per pound of body weight daily to support muscle maintenance and growth. This aligns with the need for higher protein intake to bolster body composition and overall health 2.
- Fats: Prefer plant-based sources of fats such as avocados, nuts, seeds, and olive oil. Small amounts of animal fats like butter and full-fat dairy can also be beneficial 4.
Exercise Enjoyment and Brain Health:
- Exercise should be enjoyable to sustain long-term habits. Resistance training and high-intensity work are critical, especially for brain health due to their role in lactate production, which can help reduce cognitive decline 5.
- Tailored pre-training nutrition is important, but flexibility in timing and type of meal (based on individual needs and preferences) is encouraged for optimal performance 6.
Andrew Huberman highlights that Dr. Sims’ advice is not just about avoiding menopause-related bone loss but also leveraging training and nutrition to enhance overall health span and performance.
What other key topics were discussed?
Hormonal Impacts and Menstrual Cycle:
- Menstrual Cycle Nutrition: Adjusting nutritional intake based on different phases of the menstrual cycle to enhance performance and recovery.
- Birth Control and Hormones: Effects of hormonal birth control on training and overall health.
- Menstrual Health: How menstrual fluid can offer insights into hormonal and overall health 4.
Special Considerations:
- Cold Exposure: Benefits of cold exposure for stress resilience and recovery.
- Sleep Needs: Female-specific sleep requirements and how to meet them effectively.
- Pregnancy: Guidelines for exercising during pregnancy and managing heat stress.
- Supplementation: Recommendations for creatine, vitamin D, and adaptogens to support health and performance 5 6.
Lifestyle and Enjoyment:
- Exercise Enjoyment: Importance of finding enjoyable forms of exercise to sustain long-term habits and enhance mental well-being.
- Molecular Fitness: Insights into how different types of training impact women’s molecular fitness and longevity 3.
This episode provides comprehensive advice on how women can tailor their exercise and nutrition strategies to support health, performance, and longevity throughout different stages of life.
What were the optimal nutrition insights?