Stop guessing and start testing!
CHRONIC STRESSORS = HPA Axis dysfunction -> “D.R.E.S.S. for Health Success” protocol to improve variables contributing to dysfunction… hire a HEALTH DETECTIVE to help guide your investigation and discover what is under your hood!
What does the leaky gut test find out for you?
- Provides clues for and identify healing opportunities
- Digestion and assimilation
- Immunity and infections
- Food sensitivities
- Leaky gut
- Villous atrophy
- Crypt hyperplasia
- Motivation to test SIgA, SIBO, SIgA stool, BH401H and MRT food sensitivity
Intestinal permeability is a term describing the control of material passing from inside the gastrointestinal tract through the cells lining the gut wall, into the rest of the body. The intestine normally exhibits some permeability, which allows nutrients to pass through the gut, while also maintaining a barrier function to keep potentially harmful substances (such as antigens) from leaving the intestine and migrating to the body more widely. In a healthy human intestine, small particles (< 4 Å in radius) can migrate through tight junction claudin pore pathways, and particles up to 10–15 Å (3.5 kDa) can transit through the paracellular space uptake route.https://en.wikipedia.org/wiki/Intestinal_permeability
- Epithelial individual cells lining the GIT- tight junctions- villi and microvilli (brush border)
- Nutrition is to be broken up into tiny molecules to pass through and absorb -diffuse through the cells via transcellular uptake or paracellular update, between the cells, but not much should go through
- Molecules pass through the intestinal mucosa through the epithelial cells via transcellular updates or between the cells via paracellular uptake
- Mannitol, smaller glucose molecules, readily diffuse through the epithelial cells lining the villi
- Lactulose, larger molecules, normally excluded by these cells and cannot pass through the TIGHT JUNCTIONS between the cells (paracellular update)
- Antigen presentation- bug poop, bacteria and immune complexes (antigen + immune particle)- we don’t want them coming through. Excluded on purpose and should not be able to get through.
- Creatinine- urine test measures to see how hydrated. If over hydrated- thins out results. If dehydrated- thickens the results.
How the IP Test Measures Leaky Gut:
- IP test directly measures the ability of two non-metabolized sugar molecules, mannitol and lactulose, to permeate the intestinal mucosa
- Mannitol is readily absorbed and serves as a marker of transcellular uptake through the cells and helps assess condition of the cells. It should go through in a healthy cell.
- Lactulose is only slightly absorbed and serves as a marker for mucosal barrier integrity between the cells. It is not metabolized and should be excreted. If found in urine- gone through the MB to the liver-bloodstream and excreted via kidneys-urine. Large antigen you don’t want to get through in a healthy GIT
- Influences can be made about mucosal integrity in terms of gut immunity based on what the test tells us, other labs conducted, client history and client complaints.
- Clinical correlation is always required.
- The physical aspects of a leaky gut- the function of the GIT
- The immune activation -bacteria, food sensitivities, metals… what is going on inside to crush and ruin regular cellular uptake – you don’t seem them on this test, but you can start to make assumptions.
Assessment & Interpretation of IP Test:
ELEVATED levels of LACTULOSE and MANNITOL indicate
- general increased permeability
- “LEAKY GUT”
- Elevated Lactulose recovery indicates LEAKY GUT
Mucosal Defense and Gut Healing
- The mucosal barrier—your first-line immune defense— refers to all of the mucous membranes that comprise the primary interface between the external environment and the internal environment of the body
- This mucosal barrier lets beneficial things into your general circulation and keeps harmful ones out
- In this image we see a healthy mucosal lining (left) and one with collapsed tissues—caused by inflammation— on the right
- When the finger-like projections called villi collapse, visible on the right—harmful organisms are harbored and given a safe place to thrive, while nutrient absorption becomes compromised
- The promotion of healing and protection against such damage is paramount to overall health and disease prevention.
IP Results & Correlation with Immune Responses:
Increased LATULOSE RECOVERY has been associated with:
- Food allergy
- Inflammatory bowel disease
- Other inflammatory conditions
High lactulose and high L:M ratio – confirm suspicions with low mannitol. Low recovery, poor diffusion, pore shrunk up, villous atrophy,
- Elevated MANNITOL reflects increased transcellular permeability (cell damage) through the cells which may result in the passage of small antigens across the barrier- triggering an immune response. Too much- pores are larger so small antigens can get through the cells
- is inherently an immune system issue. Tight junctions loosen up in the response to activation of the immune system
- The antigen load and the antibody reactivity to it… immune system activation.
- DUTCH Hormone test, “DRESS” protocol -STRESS, more insights with metabolic assessment, gut pathogen test, liver stress, cleaning up the edges and moving towards main problems.
- Measuring SIgA level in saliva or stool may provide additional clues
Head to Microbiome Labs to learn more about testing, supplements and gut healing protocols here …or head to www.debbiepotts.net to schedule a consultation with me to learn more about my 90-day health detective coaching program.
Vibrant Wellness offers another type of test to identify “leaky gut”… the Wheat Zoomer test.
Symptoms and conditions associated with wheat and/or gluten sensitivity include:
- Digestive discomfort/IBS
- Low vitamin D levels
- Difficulty concentrating or “brain fog”
- Low energy levels/fatigue
- Intestinal permeability (“leaky gut syndrome”)
- Skin inflammation (eczema, dermatitis, psoriasis)
- Chronic headaches or migraines
- Weight gain/weight loss
- Joint pain or numbness in the legs, arms, or fingers
The Wheat ZoomerTM requires a blood draw and fasting for at least 8 hours prior to your draw is recommended, but not required.
Comprehensive antibody recognition will simultaneously identify any of the conditions which may be associated with gluten and/or wheat, to include:
- Intestinal permeability (“leaky gut syndrome”)
- Celiac disease
- Wheat allergy
- Wheat germ agglutinin-related
- vitamin D deficiencies
- Gluten ataxia and other neurological symptoms
- Dermatitis/eczema (skin-related disorders)
- Gluten sensitivity
- Wheat sensitivity
Did you know…
1 in 7 individuals in the United States has a wheat-related disorder.https://www.vibrant-wellness.com/tests/wheat-zoomer/#1527504422745-6625ac95-ec67
As gluten- and wheat-sensitivity become better recognized in the medical community, the need for accurate and highly sensitive testing to identify affected individuals has grown. Vibrant’s answer is the Wheat ZoomerTM.
The Wheat ZoomerTM aids in the specific recognition of antibodies to wheat peptides – including gluten and non-gluten components, along with antibodies that indicate the presence of intestinal permeability. It is also a highly sensitive peptide-based array designed to detect autoimmune reactions to gluten.
Not Available in New York state
Only healthcare providers licensed in their state may order laboratory testing.