Debbie Potts Coaching

Rabbit hole dive into AMPK vs. MTOR with Coach Debbie

Today Debbie dives into the delicate role of AMPK and MTOR Pathway.  Just as insulin, cortisol, cholesterol, and glucose… MTOR isn’t bad.  It is the GOLDILOCKS Effect of everything in our body.  Our body has it’s innate intelligence to maintain homeostasis – fascinating ability to turn up or turn down different mechanisms to keep us functioning at optimal leve- until we do something TOO much or TOO little. The effectiveness of fasting or exercise may also depend on individual factors, including an individual’s health status, age, and metabolic health. Combining both fasting and exercise may have synergistic effects on AMPK activation and overall cellular health. AMPK:

  • Nutrient Sensing: Acts as a cellular energy sensor.
  • Activation: Triggered by the depletion of energy stores, resulting in a high AMP/ADP:ATP ratio.
  • Effects on Metabolism:
    • Increases the oxidation of free fatty acids (FFA) and glucose.
    • Reduces cholesterol and fatty acid synthesis.
  • Regulation by Nutrients:
    • Activated during fasting.
    • Suppressed by the presence of carbohydrates and amino acids.
  • Role in Cellular Processes:
    • Signaling to increase mitochondrial biogenesis.
    • Promotes aerobic metabolism.

mTORC1:

  • Activation: Activated by various signals, including resistance exercise.
  • Effects on Protein Synthesis and Growth:
    • Increases protein synthesis.
    • Contributes to muscle hypertrophy.
  • Activation Signals:
    • Metabolites of muscle damage.
    • Growth hormone (GH).
    • Essential amino acids (EAA) and branched-chain amino acids (BCAA).
    • Carbohydrates and insulin.
  • Inhibition by AMPK: mTORC1 is inhibited by AMPK, creating a reciprocal relationship.

Read the rest of the notes on:

https://debbiepotts.net/ampk-vs-mtor-pathway/

or watch on our YouTube channel

https://www.youtube.com/watch?v=0yUW_-43tOc

 

What are your thoughts, questions or suggestions? Which rabbit hole are we going to go down next week?  Send message to https://www.debbiepotts.net to Coach Debbie Potts.

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