Part Two…let me share my results back from 23andMe, Arivale and VIOME. Plus in Part Three I will put them together with my recent blood work and then put together with findings in Nutritional Therapy.
23andMe:
- 69% British/Irish
- 9% French and German
- Average weight
- Muscle composition: common in elite power athletes
- Saturated fat and weight: likely to be similar on diets high or low in saturated fat
VIOME: foods recommended to eat a lot or avoid based on my gut health and biodiversity:
- MY Superfoods based on my microbiome test
- Black beans
- Cilantro
- Eggs
- Filberts or hazelnuts
- Flax oil
- Kale
- Lamb
- Pumpkin seeds
- Radish
- Sunflower seeds
- Tarragon
- Yogurt (plain)
- MY Foods to Avoid: based on my microbiome diversity
- Almonds
- Bell pepper
- Brown rice
- Coffee brewed and organic
- Lobster
- Pistachios
- Plum
- White rice
ARIVALE: Single Genetic Variants: Full Negative Effect:
GENOTYPERELATED DIMENSIONS
AA: IL6R, rs2228145
The IL6R gene provides the instructions to make IL-6 receptor, a protein involved in signaling your body’s immune system response to injury and infection as part of the inflammation process. One of the primary actions of this protein is to trigger the production of CRP, a major inflammation marker.
The AA genotype at IL6R rs2228145 is associated with an increased genetic predisposition for higher CRP, a marker of inflammation. Higher blood levels of CRP are a marker of general inflammation.
CC: CRP, rs1205
The CRP gene provides the instructions to make CRP, a protein that signals your body’s immune system response to injury and infection as part of the inflammation process. Higher blood levels of CRP are a marker of general inflammation.
The CC genotype at CRP rs1205 is associated with an increased genetic predisposition for higher CRP, a marker of inflammation.
CC: PPARG, rs1801282
The PPARG gene provides the instructions to make a protein that controls the expression of many genes involved in regulating insulin sensitivity as well as the building and breaking down of fat cells.
The CC genotype at PPARG rs1801282, which is very common, is associated with an increased genetic predisposition for type 2 diabetes. This risk may be further increased when a high amount of total fat is eaten. Talk to your Coach about whether lowering the amount of fat in your diet would be beneficial for your health goals. Risk: Type 2 diabetes and dietary fat
AA: FTO, rs9939609
The FTO gene is expressed in fat cells and insulin-secreting cells of the pancreas, as well as many other tissues in the body. Research suggests that the FTO gene is associated with type 2 diabetes and obesity, although the mechanism is unknown.
The AA genotype at FTO rs9939609 is associated with an increased genetic predisposition for type 2 diabetes partly because of its effect on body weight. Talk to your Coach about how this and other variants can impact your weight depending on your diet (see your Weight Loss Genetics page).
Type 2 diabetesObesity
Human DNA is more than 99% identical. But, it’s the small differences that matter most. Explore your results below and learn more about how Arivale reports genetics.
YOUR GENOTYPERELATED DIMENSIONS: Single Genetic Variants: Human DNA is more than 99% identical. But, it’s the small differences that matter most. Explore your results below and learn more about how Arivale reports genetics.
AA: IL6R, rs2228145
The IL6R gene provides the instructions to make IL-6 receptor, a protein involved in signaling your body’s immune system response to injury and infection as part of the inflammation process. One of the primary actions of this protein is to trigger the production of CRP, a major inflammation marker.
The AA genotype at IL6R rs2228145 is associated with an increased genetic predisposition for higher CRP, a marker of inflammation. Higher blood levels of CRP are a marker of general inflammation.
CC: CRP, rs1205- full negative
The CRP gene provides the instructions to make CRP, a protein that signals your body’s immune system response to injury and infection as part of the inflammation process. Higher blood levels of CRP are a marker of general inflammation.
The CC genotype at CRP rs1205 is associated with an increased genetic predisposition for higher CRP, a marker of inflammation.
AG: AGT, rs699 – partial negative
The AGT gene provides instructions for making a protein called angiotensinogen. Once converted into its active form, it controls blood pressure by regulating the balance of fluids and salts in the body as well as the constriction of arteries.
The AG genotype at AGT rs699 is associated with an increased genetic predisposition for high blood pressure. This predisposition is even stronger if you consistently eat high-sodium (salt) foods. People with your genotype who reduce sodium often see a greater benefit on their blood pressure. Talk to your coach about ways to reduce sodium in your diet. High blood pressure, Salt
CC: PPARG, rs1801282 – full negative
The PPARG gene provides the instructions to make a protein that controls the expression of many genes involved in regulating insulin sensitivity as well as the building and breaking down of fat cells.
The CC genotype at PPARG rs1801282, which is very common, is associated with an increased genetic predisposition for type 2 diabetes. This risk may be further increased when a high amount of total fat is eaten. Talk to your Coach about whether lowering the amount of fat in your diet would be beneficial for your health goals.Type 2 diabetes and dietary fat
CT: TCF7L2: rs7903146 – full negative
The TCF7L2 gene provides the instructions to make a protein that controls the expression of many genes involved in the function of insulin-secreting cells. Insulin is a hormone that is essential to control blood sugar.
The CT genotype at TCF7L2 rs7903146 is associated with an increased genetic predisposition for type 2 diabetes. A diet higher in saturated fat may lead to decreased insulin sensitivity in people with the CT or TT genotypes. Talk to your Coach about whether lowering saturated fat in your diet would be beneficial for your health goals. Also, since being overweight is a major risk factor for type 2 diabetes, discuss how this genetic variant and others can impact your weight depending on your diet (see your Weight Loss Genetics page). Type 2 diabetesInsulin sensitivity and saturated fat
AA, FTO, rs9939609
The FTO gene is expressed in fat cells and insulin-secreting cells of the pancreas, as well as many other tissues in the body. Research suggests that the FTO gene is associated with type 2 diabetes and obesity, although the mechanism is unknown.
The AA genotype at FTO rs9939609 is associated with an increased genetic predisposition for type 2 diabetes partly because of its effect on body weight. Talk to your Coach about how this and other variants can impact your weight depending on your diet (see your Weight Loss Genetics page). 2 diabetesObesity
Part Three to come – matching current lab work with genetics and Nutritional Therapy functional evaluation results!
The WHOLESTIC Method,
Debbie Potts
